Telomere length- A biological marker of ageing

Telomere length: a marker of disease susceptibility?

0889-1591/$ see front matter 2013 Elsevier Inc. All rights reserved. http://dx.doi.org/10.1016/j.bbi.2013.08.004 DOI of original article: http://dx.doi.org/10.1016/j.bbi.2013.06.009 q Work on this paper was supported in part by NIH Grants CA158868, CA131029, AG038621, and CA172296, as well as Ohio State Comprehensive Cancer Center Core Grant CA16058, and NCRR Grant UL1RR025755. ⇑ Corresponding ...

Telomere length as a marker of cellular ageing is associated with prevalence and progression of metabolic syndrome

Révész (2016)-The interplay between biological stress and cellular aging: an epidemiological perspective Abstract Context. Metabolic Syndrome (MetS) clusters risk factors for age-related conditions including cardiovascular disease and diabetes. Shorter telomere length (TL), a cellular marker for biological age, may predict an individual's deteriorating metabolic condition. Objective. We examine...

Ageing--a biological perspective.

Lack of association between leukocyte telomere length and genetic variants in two ageing-related candidate genes.

BACKGROUND Leukocyte telomere length, a putative marker of ageing, is a highly variable and heritable complex trait. In order to determine the possible underlying genetic variants for leukocyte telomere length variation, we conducted an association study of leukocyte telomere length and two candidate genes for ageing-related traits, TGFB1 and KLOTHO, in a female Caucasian dizygotic twin populat...

Leukocyte telomere length: the telomere tale continues.

In culture, replicating human somatic cells display progressive telomere shortening. Ultimately, such cells either undergo apoptosis or enter a state of replicative senescence that is triggered by critically shortened telomeres. Accordingly, telomere length is an index of both the replicative history and the replicative potential of human somatic cells in culture (1). Most replicating human som...